Basic Information
VIS ID
TVIS10009957
Fusion event
HBV-LOC107985905 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1090
Orient
-
Integrated sequence
GTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGC| |TTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCT
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
84467268/84240144 (Hg38)
End
84467268/84240144 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
LOC107985905
Nearest miRNA
hsa-mir-1285-2/Upstream/4373561; hsa-mir-10b/Downstream/1543456;
Nearest TSS
ENST00000437798/Upstream/717330; ENST00000440495/Downstream/74964;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2772587, chr2-CpG: 27/Downstream/50446
Nearby gene
DHFRP3(-1382375) ; FUNDC2P2(+50538) ;
Upstream sequence
ggtcaaatggaggcttcttgctcaagtggaggatcaaccagccacagatggtaaagaagagagcacaaagagggcacaatggatactgaactgctctcag
Downstream sequence
cctggaagtgatacctatgtggccagaatgactcacatggccatcctaattgcaaggaagtttgagaaCTATCAAGGACCACAAGTACTCAGTGAGCACT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate