Basic Information
VIS ID
TVIS10009961
Fusion event
HBV-NOL4L integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3166
Orient
-
Integrated sequence
TACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCC| |TCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr20
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
31087912/32500109 (Hg38)
End
31087912/32500109 (Hg38)
Orient
-
Location type
Intronic
Target gene
NOL4L
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/262262; hsa-mir-1-1/Downstream/1549010;
Nearest TSS
ENST00000382410/Upstream/16527; ENST00000620523/Downstream/9850;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/15236, chr20-CpG: 103/Downstream/36077
Upstream sequence
gagtatttaacaaatgatgctgagacaaaagggttaagcggaatctgtatctcagaatacgtcagcataagctccaaatggatcaaagattaaatataaa
Downstream sequence
aaatgaaaataaaaacatgtatgctttttgctctgtcagctggaagagcctgcaagaaaggatacttcagtaccaatgggcacacatagtgcccagatct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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