Basic Information
VIS ID
TVIS10009962
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1739
Orient
-
Integrated sequence
TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGG| |AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTA
Host Sequence
Chromosome
chr20
Cytoband
q12
Reference genome
GRCh37/hg19
Start
38495269/39866627 (Hg38)
End
38495269/39866627 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/1349995; hsa-mir-1-1/Downstream/1302396;
Nearest TSS
ENST00000382410/Upstream/80906; ENST00000432633/Downstream/137850;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/816169, chr20-CpG: 92/Downstream/816111
Nearby gene
LINC01734(-641878) ; MAFB(+819248) ;
Nearest cancer related gene
MAFB(OG, +819248) ;
Upstream sequence
TGTGTGTGTGTGTGTGTGACagagagagagagagagagagaaagTTTTTACAAGAGTTTGGGTAGGAAGAAGCAATAATTTGATAGATATAAAGCACACA
Downstream sequence
TTTGGGAATCAAAGAGGACCATGGAAGAACATTTTTAGAGGACTTGATAGCCTGTTGGGTATGTTGCCTATTAAGGGAGATTGAGGACTTTGGTGTCTGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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