VISDB Viral Integration Site DataBase

VIS ID

TVIS10009964

Fusion event

HBV-HNF4A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1758

Orient

-

Integrated sequence

AGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAG| |GTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTC

Chromosome

chr20

Cytoband

q13.12

Reference genome

Start

End

43004306/44375666 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-24-3p ; hsa-mir-34a-5p ; hsa-mir-197-3p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-766-3p ; hsa-mir-34b-5p ; hsa-mir-765 ; hsa-mir-629-5p ; hsa-mir-216a-5p ; hsa-mir-143-3p ; hsa-mir-4776-3p ; hsa-mir-6875-3p ; hsa-mir-3180-5p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-488-5p ; hsa-mir-24-1-5p

Nearest miRNA

hsa-mir-103a-2/Upstream/3206588; hsa-mir-1-1/Downstream/32454;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/48578, chr20-CpG: 37/Downstream/100100

Nearest cancer related gene

HNF4A(TSG, No orient, 0)

Upstream sequence

gaggaaaggtgattcggccaaagtcatacagtaagttagtggcagagccaagactagaaTGGTGGACTGTGGGTGTTGGAAGGGAACTTTGAGGTTGTTA

Downstream sequence

GGGCAGCCTTTCCTAAGGCGAGGCCCCTCAgacaagaaggattctattgttagatgtttgaaaactgctgaattaaagaaagctgcacaaatttcattat