DDX27 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009969
Fusion event
HBV-DDX27 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2227
Orient
+
Integrated sequence
TTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCA| |CTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAAC
Host Sequence
Chromosome
chr20
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
47854024/49237487 (Hg38)
End
47854024/49237487 (Hg38)
Orient
+
Location type
Intronic
Target gene
DDX27
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/2070429; hsa-mir-1-1/Downstream/626372;
Nearest TSS
ENST00000382410/Upstream/3649; ENST00000623640/Downstream/7265;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/17957, chr20-CpG: 72/Downstream/40534
Upstream sequence
TAATTCTGTGTCAAAGAGCTCACCACTGGTAGCATTTAGGTGTATGTCTTTTCAAACCATTTTTCCTTTCTTAAATGTCCCTTTTATTTTTTTCATTTTC
Downstream sequence
ATTGTCttcatttaatcagcgactagttattgagtcctgctgtgggcctagtgctattgattctgttctaggtgctggggatacagcagggaacaaagca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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