Basic Information
VIS ID
TVIS10009970
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
639
Orient
-
Integrated sequence
TCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTC| |CTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTA
Host Sequence
Chromosome
chr20
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
62918470/64287117 (Hg38)
End
62918470/64287117 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-1/Upstream/210107;
Nearest TSS
ENST00000382410/Upstream/15635; ENST00000279067/Downstream/3268;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/16556, chr20-CpG: 92/Downstream/29178
Nearby gene
PCMTD2(-10891) ; LINC00266-1(+3268) ;
Upstream sequence
gttaggggttagggttagggttagggttacggttagggttagggttagggttagggtagggttagggttaggggttaggggttagggttagggttagggt
Downstream sequence
aagggtaagggttaggattaggggttagggttagggttagggttagggttagggttagggtagggttagggttagggttagggttaggggttaggggtta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate