VISDB Viral Integration Site DataBase

VIS ID

TVIS10009972

Fusion event

HBV-APP integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2147

Orient

+

Integrated sequence

CACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAG| |AGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTT

Chromosome

chr21

Cytoband

q21.3

Reference genome

Start

End

27442380/26070064 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-106b-5p ; hsa-mir-101-3p ; hsa-mir-520c-3p ; hsa-mir-106a-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-15a-5p ; hsa-mir-130a-3p ; hsa-let-7d-5p ; hsa-let-7a-5p ; hsa-mir-16-5p ; hsa-mir-532-3p ; hsa-mir-500a-5p ; hsa-mir-484 ; hsa-mir-423-3p ; hsa-mir-328-3p ; hsa-mir-222-3p ; hsa-mir-196a-5p ; hsa-mir-1260b ; hsa-mir-3620-3p ; hsa-let-7a-2-3p ; hsa-let-7g-3p ; hsa-mir-6504-3p ; hsa-mir-455-3p ; hsa-mir-298 ; hsa-mir-490-5p ; hsa-mir-545-5p ; hsa-mir-3688-3p ; hsa-mir-3662 ; hsa-mir-15b-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-144-3p ; hsa-mir-4786-5p ; hsa-mir-4698 ; hsa-mir-4495 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-567 ; hsa-mir-944 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6881-3p ; hsa-mir-7111-3p ; hsa-mir-6780a-3p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-1229-5p ; hsa-mir-3606-5p ; hsa-mir-6073 ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-3908 ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-4709-3p ; hsa-mir-5093 ; hsa-mir-5584-5p ; hsa-mir-6502-3p ; hsa-mir-3646 ; hsa-mir-3120-3p ; hsa-mir-551b-5p ; hsa-mir-4484 ; hsa-mir-424-3p ; hsa-mir-548ad-3p ; hsa-mir-3672 ; hsa-mir-4461 ; hsa-mir-6864-3p

Nearest miRNA

hsa-let-7c/Upstream/496020; hsa-mir-3197/Downstream/883897;

Nearest TSS

Nearest CpG islands

None/Target, chr21-CpG: 261/Upstream/334164, chr21-CpG: 127/Downstream/99511

Upstream sequence

CACCTTTTACCAGGCATTACAATATTGCTATGAGTTCACAAAGCTCTGTTAGAGCAGAGGAAAAAGAAGGATTTGAATTCTGTCACTGTACTAGCAACAC

Downstream sequence

CACCTAGGGATGAGGAAGACAATATCTAATAGAATAACAAATAAAGTAAGTATACATGATTCATCAAGCTCTTCAATAAAAATGTATTTTAGAATTTATC