Basic Information
VIS ID
TVIS10009982
Fusion event
HBV-LOC102724289 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
152398173/152680384 (Hg38)
End
152398173/152680384 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
LOC102724289
Nearest miRNA
hsa-let-7g/Upstream/1114389; hsa-mir-1224/Downstream/6602262;
Nearest TSS
ENST00000440867/Upstream/32238; ENST00000305097/Downstream/154309;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/410848, chr3-CpG: 120/Downstream/154429
Nearby gene
MBNL1(-214604) ; P2RY1(+154563) ;
Upstream sequence
atgtagctataatatttccctgctgatctgggggctgtattctaacagggaactgccaagcctctaaatcaccctctcttctagcttgctgaattcctac
Downstream sequence
aaatattacccaAGTCTtgtataaatgatgacactttaggttctaagtaactgaaacaaaactcagcttcaatttctcttaggcaaaagggaaactatag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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