Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10009985
Fusion event
HBV-MCCC1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|middle S protein|
Start
134
Orient
+
Integrated sequence
CCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAG| |GATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTC
Host Sequence
Chromosome
chr3
Cytoband
q27.1
Reference genome
End
182804259/183086471 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-let-7g/Upstream/6571320; hsa-mir-1224/Downstream/800329;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/21683, chr3-CpG: 60/Downstream/12512
Upstream sequence
CCCACTATAACTGAATATTTTCCCCCAGCATTGAGTCAGTCCCAACCCATCCCCCTCCAAGAAATTCCCCCTTGAACCTTCCAAGCCACATCTCATTGTC
Downstream sequence
CTTTCCACCTATTTCCCAAAGGATCTAAAGTACACAGGATCCAGTAAAAAGGCAGACTGGCTGAGAAATGAGATGGGACATGCCTAGTTTACAATGATAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.