Basic Information
VIS ID
TVIS10009987
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
67126524/67076100 (Hg38)
End
67126524/67076100 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/6458230; hsa-mir-12124/Downstream/149364;
Nearest TSS
ENST00000440867/Upstream/77175; ENST00000498247/Downstream/220200;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/77251, chr3-CpG: 45/Downstream/578104
Nearby gene
KBTBD8(-64892) ; MIR4272(+149364) ;
Upstream sequence
CCTCACACCAAACCCCATGAGGCAGAGGCCAGGCTGCTCCTGTGAAGCCACGATGAACTAGCGATGGAAAACCCTTGAGTCAAGGTCAACAcagagccag
Downstream sequence
GCAGGTGAGCAGTAGAGTTCATTCGAATTCACTTCCCTTGTTCAGGCCCCTCCCGCCGTGCCATTGCTATTCTTTCTGCGTGGGTATTGCTCATTCTTCG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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