Basic Information
VIS ID
TVIS10009991
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr3
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
94860557/95141713 (Hg38)
End
94860557/95141713 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/7915436; hsa-mir-12124/Downstream/1218251;
Nearest TSS
ENST00000440867/Upstream/178783; ENST00000506569/Downstream/1476523;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/203398, chr3-CpG: 49/Downstream/1635060
Nearby gene
LINC00879(-150388) ; EPHA6(+1672868) ;
Upstream sequence
tgATGCATATGAGCTTTAATATCCTGACAAGAGAAATAAGTATCTCATTGCCATTTTCTCAAAAGTAGGATAGCTTCATTTATGCTACTGAAATAAACAT
Downstream sequence
ggttacaattaatttattaacctgtgtggtagacacaggtgtgtttcttttataatttgtcattacattctacagataTTCTACAGATAGCCTAATATTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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