Basic Information
VIS ID
TVIS10009992
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
657
Orient
+
Integrated sequence
TCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCA| |GCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATT
Host Sequence
Chromosome
chr3
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
94861189/95142345 (Hg38)
End
94861189/95142345 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/7916068; hsa-mir-12124/Downstream/1217619;
Nearest TSS
ENST00000440867/Upstream/179415; ENST00000506569/Downstream/1475891;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/204030, chr3-CpG: 49/Downstream/1634428
Nearby gene
LINC00879(-151020) ; EPHA6(+1672236) ;
Upstream sequence
tcggcaagctgaggcaggagaatcaggcagggaggttgcagtgagccgagatggcagcagtaccgtccagctttggctcggcatcagagggagaccgtgg
Downstream sequence
ATAGTTTTTTTCATCACCTGTGGGTCCTATTCATTTCACACAATTCTGCTTACCACAGGAGAGTGAGACATCATTCTATTGTCTGTGTGGATGGAAACTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate