Basic Information
VIS ID
TVIS10009993
Fusion event
HBV-MIR548G integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2482
Orient
+
Integrated sequence
CCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAAC| |TTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAAT
Host Sequence
Chromosome
chr3
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
99542014/99823170 (Hg38)
End
99542014/99823170 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
MIR548G
Nearest miRNA
hsa-let-7g/Upstream/3463131; hsa-mir-12124/Downstream/141144;
Nearest TSS
ENST00000440867/Upstream/5258; ENST00000479555/Downstream/25442;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/4991, chr3-CpG: 36/Downstream/52955
Upstream sequence
ctgtgaggttttggtatcaggatgatgctggcctcgaaaaatgagttagagaggagtccctctttttctattgtttggaatagtttcagaagaaatggta
Downstream sequence
AAGTTTACTCTTTTAAAGAACACTGGTTACTTGGAGCTACAAATAAGCAGCTTTTCCATTTGGGCTTTGAGAACCATTTCTGCCAGTaactcaaacctga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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