Basic Information
VIS ID
TVIS10009995
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1689
Orient
-
Integrated sequence
GCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAAC| |GACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGG
Host Sequence
Chromosome
chr4
Cytoband
q27
Reference genome
GRCh37/hg19
Start
122631287/121710132 (Hg38)
End
122631287/121710132 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/7053278; hsa-mir-1305/Downstream/3797127;
Nearest TSS
ENST00000502981/Upstream/13019; ENST00000424958/Downstream/54162;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/12664, chr4-CpG: 82/Downstream/54573
Nearby gene
ANXA5(-13140) ; TMEM155(+48798) ;
Upstream sequence
taaaataaaataaatcaaacacgtctgttcttactgagcctaagctaaccaccttcttataattaaatgttacatttttagccttcaaatttttttgttt
Downstream sequence
aaaaaaaaaaaaaagtttactgttttaaaccaccaaatttgagatgatttgttacagaacaatagatgactaatccaAAGTTTGCTTACAGGGGTCAACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate