Basic Information
VIS ID
TVIS10009997
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1803
Orient
-
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |CGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
143786975/142865822 (Hg38)
End
143786975/142865822 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/17358515; hsa-mir-1305/Downstream/477638;
Nearest TSS
ENST00000502981/Upstream/18390; ENST00000510377/Downstream/319007;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/18562, chr4-CpG: 99/Downstream/318709
Nearby gene
INPP4B(-19371) ; USP38(+319095) ;
Nearest cancer related gene
INPP4B(TSG, -19371) ;
Upstream sequence
ATTCTGCAAATATGTATGGGCCACTTTTATGTTATGAGCATGCATGTCCTAGATATCAGCACTGGAGATATGACAATGATAGGGCACAAGCTGTAACTTC
Downstream sequence
ggggaggctgaggcaggagaatggcgtgaacccaggaggtggagcttgcagtgagccaagatcgcaccactgcacctccagcctgggcggcagagcgaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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