Basic Information
VIS ID
TVIS10010000
Fusion event
HBV-LOC107986338 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1795
Orient
-
Integrated sequence
CCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAA| |TTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
191032724/190111569 (Hg38)
End
191032724/190111569 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107986338
Nearest miRNA
hsa-mir-12113/Upstream/5173129;
Nearest TSS
ENST00000502981/Upstream/47067; ENST00000616166/Downstream/62205;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/19115, chr4-CpG: 24/Downstream/61564
Nearby gene
DUX4L2(-19248) ;
Upstream sequence
CCAAGCTTCCAAATCATATGTTTTATGAAAAAGGTACATTTCTTTACAGACTTCCAGTATCAAAGAAGGTTTTTAAAATCTTTAAAATAGCTTAGATAAT
Downstream sequence
TCACCACAGTGAACTGTAGGTTGGACAATAATGAGTGCCTCGAGCCAAGTCGCAgcaagcctagtttcaggctccctcccccagaagtcactgggctgag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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