Basic Information
VIS ID
TVIS10010003
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2222
Orient
-
Integrated sequence
TTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTG| |TCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTA
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
53055367/52189201 (Hg38)
End
53055367/52189201 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/4536458; hsa-mir-1243/Downstream/523481;
Nearest TSS
ENST00000502981/Upstream/110857; ENST00000503051/Downstream/439165;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/112119, chr4-CpG: 141/Downstream/469596
Nearby gene
SPATA18(-91909) ; USP46(+401760) ;
Upstream sequence
tgtgtgaccttgggggcgtggcttctcctctctgagcctgctttggtgctttcctccagagaattggAGGAGAGAGCTGAGCGGCCCCACATTGCTGCCC
Downstream sequence
gcattctctcaataaagaccaatgtcatttcagccaaggggaattaggaaaagacagttacatggggaccagcacaatctttcatcaaggattgacctgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate