Basic Information
VIS ID
TVIS10010005
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1804
Orient
-
Integrated sequence
ATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGC| |GCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCAT
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
60187652/59321934 (Hg38)
End
60187652/59321934 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA4B
Nearest miRNA
hsa-mir-12113/Upstream/6609187; hsa-mir-1243/Downstream/1600685;
Nearest TSS
ENST00000502981/Upstream/169100; ENST00000509559/Downstream/308390;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2125985, chr4-CpG: 222/Downstream/1878231
Upstream sequence
tgagattgcgtgcgccattgcactccagcctgggcgacaagagcaaaaatctgtctcaaaaaaaaaaaaaaaaagaaaagaaaaagaaaaTACAAAGTCA
Downstream sequence
TTTTCTACCAATAACTTCCCAGTTGGTCCCAAACCCTAATTTGATTCCTCTTCCTCATTATATTTCTCAATGAAGTAATTTCTGAATCTTCTTATTCCAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate