Basic Information
VIS ID
TVIS10010007
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1476
Orient
-
Integrated sequence
TGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCT| |TGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGA
Host Sequence
Chromosome
chr4
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
96575078/95653927 (Hg38)
End
96575078/95653927 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA4E
Nearest miRNA
hsa-mir-12113/Upstream/8353344; hsa-mir-1243/Downstream/3343460;
Nearest TSS
ENST00000502981/Upstream/104721; ENST00000295266/Downstream/186092;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/104084, chr4-CpG: 19/Downstream/2489524
Nearby gene
UNC5C(-104717) ; PDHA2(+186161) ;
Nearest cancer related gene
UNC5C(TSG, -104717) ;
Upstream sequence
aatttgacacattagacttgatcacaaactgtaacttttaagctgggtgcagtagcacacacttgtagtcccagctatttgggaggctgaggcaggagga
Downstream sequence
tttggtaggactatttattttcttttagatggatacccagtaatgggattgctgggttgaatggtagttctaagttctttgataaatctctaaactactt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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