VISDB Viral Integration Site DataBase

VIS ID

TVIS10010017

Fusion event

HBV-AHRR integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1829

Orient

+

Integrated sequence

GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

360115/360000 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-26a-5p ; hsa-mir-18a-5p ; hsa-mir-125b-5p

Nearest miRNA

hsa-mir-10397/Downstream/702896;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/589, chr5-CpG: 24/Downstream/10070

Nearest cancer related gene

AHRR(TSG, No orient, 0)

Upstream sequence

gacttcactccatttcccaacaaattcctcatctctatctgagaccacctccgcctggaccttattgtccatatcactatgaacattttggtcaaagcca

Downstream sequence

TTttatggactggatgtttgtctcatcccttcacctattcatatagtgaaaccctaattcccagtgtggccgtatttgtaggtgggtccgcttaggaaga