VISDB Viral Integration Site DataBase

VIS ID

TVIS10010019

Fusion event

HBV-ARHGEF28 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

3109

Orient

-

Integrated sequence

TGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAA| |TCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG

Chromosome

chr5

Cytoband

q13.2

Reference genome

Start

End

72995410/73699585 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-19b-3p ; hsa-mir-203a-3p ; hsa-mir-4635 ; hsa-mir-302a-5p ; hsa-mir-7161-3p ; hsa-mir-338-3p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-1226-3p ; hsa-mir-634 ; hsa-mir-6771-3p

Nearest miRNA

hsa-mir-10397/Upstream/820922; hsa-mir-103a-1/Downstream/9140570;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/72883, chr5-CpG: 29/Downstream/209900

Upstream sequence

accctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccc

Downstream sequence

TTTGTGGGCCATCTGGGTGTAGAAAAGTGCTGAGCAGAGGCGTGCTGATGGGAGGGAATTTGAAAATCTGGGTTACTGAAACAATACATTTAAGCATCTA