Basic Information
VIS ID
TVIS10010023
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
620
Orient
-
Integrated sequence
GGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATC| |CTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCC
Host Sequence
Chromosome
chr6
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
139679919/139358782 (Hg38)
End
139679919/139358782 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/923488; hsa-mir-1202/Downstream/846470;
Nearest TSS
ENST00000381078/Upstream/66643; ENST00000414038/Downstream/15431;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/191545, chr6-CpG: 18/Downstream/14300
Nearby gene
TXLNB(-66711) ; CITED2(+13473) ;
Nearest cancer related gene
CITED2(TSG, +13473) ;
Upstream sequence
AGCAGAAATTGCAACATCACGAAGGCGATTTTAAAAGGCTGGGCCATCAGATGTCATATCTGAGAAATACAGTTAAAAGGCTGGTGAAGAATTAAGGATT
Downstream sequence
gaagaaggacgtgtttgcttcctcttctgccatgattgtaagtttcctgaggcctccacagccatgctgaactatgagtcaattaaatctctttcctgta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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