Basic Information
VIS ID
TVIS10010026
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1527
Orient
+
Integrated sequence
TACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGC| |GCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAAC
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
33584648/33616871 (Hg38)
End
33584648/33616871 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/178434; hsa-mir-10398/Downstream/81257;
Nearest TSS
ENST00000381078/Upstream/23533; ENST00000605930/Downstream/3494;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/23459, chr6-CpG: 124/Downstream/3969
Nearby gene
LINC00336(-23533) ; ITPR3(+4508) ;
Upstream sequence
tgtcaagggaatgtgctgtcaacttatttatcactgatgtttatcagtagtgatggtaagcctcattgcatgcctgaggttgtgtttgtcaggtgttttc
Downstream sequence
gggaggtggagcttgcagtgagctgagatcgtgccactgcactccagcctgggcgacagagcgagactccatctaaaaaaaaataaaaaaaaaaagctga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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