VISDB Viral Integration Site DataBase

VIS ID

TVIS10010028

Fusion event

HBV-BTBD9 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1811

Orient

+

Integrated sequence

AAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAG| |CACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC

Chromosome

chr6

Cytoband

p21.2

Reference genome

Start

End

38303506/38335730 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-30e-5p ; hsa-mir-149-5p ; hsa-mir-26a-5p ; hsa-let-7b-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-5692a ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-6731-5p ; hsa-mir-8085 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-4719 ; hsa-mir-1178-3p ; hsa-mir-369-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-6781-5p ; hsa-mir-4268 ; hsa-mir-4660 ; hsa-mir-766-3p ; hsa-mir-7112-5p ; hsa-mir-338-3p ; hsa-mir-4530 ; hsa-mir-3918 ; hsa-mir-6736-3p ; hsa-mir-3065-3p ; hsa-mir-6871-3p ; hsa-mir-6749-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-600 ; hsa-mir-2116-3p ; hsa-mir-5193 ; hsa-mir-4700-3p ; hsa-mir-374c-5p ; hsa-mir-4643 ; hsa-mir-466 ; hsa-mir-4789-3p ; hsa-mir-655-3p

Nearest miRNA

hsa-mir-1236/Upstream/780308; hsa-mir-10398/Downstream/738584;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/515956, chr6-CpG: 77/Downstream/303699

Upstream sequence

TTCTAATGCCTTTATTTTGAATATGAGTTTGAACATAGCCTATATTCATGGGGGCTATTATTCTAGGGTCATTTACACTGTAAGGATGCATATGTTCTTT

Downstream sequence

aatttatttatttatttttttgagatggagtctcactctgttgcccaggctggagtgcagtggcacaatcttggctcaccgcaacctttgctttccggat