Basic Information
VIS ID
TVIS10010034
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1727
Orient
-
Integrated sequence
GCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTA| |AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
152281835/152584750 (Hg38)
End
152281835/152584750 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7I
Nearest miRNA
hsa-mir-10399/Upstream/1151111; hsa-mir-153-2/Downstream/4989586;
Nearest TSS
ENST00000635602/Upstream/120964; ENST00000488782/Downstream/79254;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/119722, chr7-CpG: 51/Downstream/91145
Nearby gene
LINC01003(-119205) ; XRCC2(+61752) ;
Upstream sequence
aagcctgtaggcgttgcagttggcagatgtgtgtttggttcctggctctctcctgctattgtttacctcaaattttctcctctgtaaattggggataata
Downstream sequence
tgaacaaaggtctctggttttcctaggcagaggaccctgcggccttggccttccgcagtgtttgtgtccctgggtacttaagattagggagtggtgatga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate