Basic Information
VIS ID
TVIS10010036
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1838
Orient
+
Integrated sequence
GAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCT| |AATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACT
Host Sequence
Chromosome
chr7
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
15610001/15570376 (Hg38)
End
15610001/15570376 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-339/Upstream/8503331; hsa-mir-10399/Downstream/2556844;
Nearest TSS
ENST00000635602/Upstream/8361; ENST00000451240/Downstream/97571;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1578788, chr7-CpG: 17/Downstream/829121
Nearby gene
AGMO(-8361) ; MEOX2(+40836) ;
Upstream sequence
CCTATGTCTAGTTTAAAATTTGGCAATCTATTTTGATTTCAGATACCAGAGTAAATACTGTAAGTTTATTGTTACCTGTATGGTCAGAATCTTTTGGTAA
Downstream sequence
atggtccaatgcattgtatgaaatgatcattttgctttttttgtgaagaatggactttagagaggtaggctggaagcagaggactcttcataaatagttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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