VISDB Viral Integration Site DataBase

VIS ID

TVIS10010039

Fusion event

HBV-TNS3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

757

Orient

-

Integrated sequence

GCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATT| |GGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGA

Chromosome

chr7

Cytoband

p12.3

Reference genome

Start

End

47370506/47330908 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-21-5p ; hsa-mir-342-3p ; hsa-let-7i-5p ; hsa-mir-8070 ; hsa-mir-5003-5p ; hsa-mir-8485 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-1178-3p ; hsa-mir-6071 ; hsa-mir-6749-3p ; hsa-mir-377-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-5088-3p

Nearest miRNA

hsa-mir-1183/Upstream/2449108; hsa-mir-10399/Downstream/9624877;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/76220, chr7-CpG: 95/Downstream/205803

Upstream sequence

tcgagaccatcctggctaacacggtgaaaccccatctctactaaaaatacagaaaTTggccgggcacggtggctcacgcctgtaatcccagcactttttg

Downstream sequence

GGGTCCTACAGGGGCTGCATCCCATCACCTCCCACATCTCTGTCCCACCGGACTCGGGCGAACCTTATGTGTGCACACAATAAGAGGAACCCTGGACCAG