VISDB Viral Integration Site DataBase

VIS ID

TVIS10010041

Fusion event

HBV-GTF2I integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|Polymerase|

Start

1527

Orient

+

Integrated sequence

TACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGC| |GCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAAC

Chromosome

chr7

Cytoband

q11.23

Reference genome

Start

End

74113716/74699386 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-10a-3p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-99a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-580-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3121-3p

Nearest miRNA

hsa-mir-10525/Upstream/103360; hsa-mir-10399/Downstream/1215811;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/40634, chr7-CpG: 124/Downstream/88603

Upstream sequence

gcaacatagcgagatcccctctctacaaacaataaattagccaggtgcagtgacatgtgtctgaagatccagctatttgggaggctgaggcaggaggact

Downstream sequence

gtttcaagtgattctcctgcctcagccccctgagtaactaggattacaggtgtccgccaccatgcccggctaatttttgtgttaaattttagtagagatg