TMEM74 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010045
Fusion event
HBV-TMEM74 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1803
Orient
-
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |CGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
109698555/108686326 (Hg38)
End
109698555/108686326 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM74
miRNAs that regulate target gene
hsa-mir-122-5p
Nearest miRNA
hsa-mir-12123/Upstream/4201861; hsa-mir-10400/Downstream/3957167;
Nearest TSS
ENST00000518652/Upstream/105264; ENST00000518632/Downstream/101268;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/242292, chr8-CpG: 36/Downstream/100874
Nearby gene
EMC2(-199419) ; TMEM74(+96791) ;
Upstream sequence
CTGATTCCCAAAGTCTACTCAACAATTTCCTATAAAAGCTATGTTCCTTTTAGAAAGGGTGCTGACATGAAATGTTCAGATTTACTTAGGCAAAGTAGCT
Downstream sequence
tagctgggactacaggcacctgccaccgcgcccggctaattttttttttgtatttttagtagagaccaggtttcaccgtgttagccaggatggtctcgat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate