Basic Information
VIS ID
TVIS10010047
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
847
Orient
-
Integrated sequence
ATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAA| |AACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGT
Host Sequence
Chromosome
chr8
Cytoband
q24.11
Reference genome
GRCh37/hg19
Start
117841776/116829537 (Hg38)
End
117841776/116829537 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/4185954; hsa-mir-10400/Downstream/45191;
Nearest TSS
ENST00000518652/Upstream/59347; ENST00000521487/Downstream/19946;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/62630, chr8-CpG: 81/Downstream/44576
Nearby gene
UTP23(-54855) ; RAD21(+16397) ;
Upstream sequence
taggctaaaacagtaaggtcaagttgtttggacagaaaggctacagggtgtggtcctggctcttgtgtaagaattctgaccatgctaaccatgcctagga
Downstream sequence
Ggtatggtctaagagtagaggatcagtgttgagggaatgggcaaaatgtatcattgtaccatgcttgtcacttagatcaccctccagcctggcccctgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate