PVT1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010049
Fusion event
HBV-PVT1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1790
Orient
-
Integrated sequence
ACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGC| |ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
128878663/127866417 (Hg38)
End
128878663/127866417 (Hg38)
Orient
-
Location type
Intronic
Target gene
PVT1
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-1204/Upstream/70389; hsa-mir-10400/Downstream/94216;
Nearest TSS
ENST00000518652/Upstream/11262; ENST00000520913/Downstream/24211;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/16439, chr8-CpG: 122/Downstream/2072709
Nearby gene
MIR1204(-70389) ; PVT1(+24211) ;
Nearest cancer related gene
PVT1(OG, No orient, 0)
Upstream sequence
aaagaaaaagaggtttaatggactcatggttccacgtggctggggaggcctcacaaatcaaggtggaaggcaaaaggtatgttttacatggcagcaggca
Downstream sequence
TGCTGACCTGCTGGTGGCTTGTCCTGCTCTTGGATCATAGGCACTGGGACATCCTGCCTTCCTTCAGTGTCCCCTCCCACTCCCTCTCCTTCAGCATCAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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