Basic Information
VIS ID
TVIS10010051
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2080
Orient
-
Integrated sequence
GTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTC| |TTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATAT
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
36519418/36661900 (Hg38)
End
36519418/36661900 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/6704552; hsa-mir-10400/Downstream/4609148;
Nearest TSS
ENST00000518652/Upstream/566854; ENST00000522417/Downstream/117264;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1425307, chr8-CpG: 351/Downstream/1032526
Nearby gene
UNC5D(-867237) ; KCNU1(+122424) ;
Nearest cancer related gene
UNC5D(TSG, -867237) ;
Upstream sequence
gttaatttcaagtgtcctttaccgtacttactttggtccctccaagagtcctgggactctcgggtcatcctttatctcctgaattctaatctccatgtgg
Downstream sequence
caaaacaaaaccacaatgaaatatcatctcactccagttaaaatggccattatcaattagacaaaaaaaaaagcacatactgcagatgtggggaaagggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate