Basic Information
VIS ID
TVIS10010052
Fusion event
HBV-ADAM2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1831
Orient
+
Integrated sequence
CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC| |TCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGG
Host Sequence
Chromosome
chr8
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
39695797/39838278 (Hg38)
End
39695797/39838278 (Hg38)
Orient
+
Location type
upstream
Target gene
ADAM2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-124-1/Upstream/9880930; hsa-mir-10400/Downstream/1432770;
Nearest TSS
ENST00000518652/Upstream/51; ENST00000522840/Downstream/11;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/315264, chr8-CpG: 20/Downstream/1059367
Upstream sequence
CTTCTGCATTTTTATTTTGGTACACATACTATAACGCCCTTTTGAAAATGTATCATCAACTGCTGATTTGGAAGCCTACAACTTTAAAATAGAATCTGAA
Downstream sequence
AAGAGGTAGGCGGCTGGGAGAGCCCAGGTGGGCTGAGGTTGGGTGTGGTGCGCTGTGGAACGTGCGAGCTCCTGAGCCCTGTCTCTTGCAGGACAAGCAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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