Basic Information
VIS ID
TVIS10010058
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
175
Orient
+
Integrated sequence
TCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAG| |GATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAA
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
6761614/6904092 (Hg38)
End
6761614/6904092 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3674/Upstream/158848; hsa-mir-10400/Downstream/1184849;
Nearest TSS
ENST00000518652/Upstream/26070; ENST00000526235/Downstream/21984;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/68479, chr8-CpG: 81/Downstream/187735
Nearby gene
DEFB1(-26085) ; DEFA6(+20602) ;
Nearest cancer related gene
DEFB1(TSG, -26085) ;
Upstream sequence
tccagtcttcttgagtgatatctctggatgtgggagtgaaccaaatgaatagcgcctgaagcgaacccctagcaaaccacagcagccctacagaggaggg
Downstream sequence
atgggctaaggcCCAGTGCCTTCTGTGTGGCTAGGCTCATGGCTGTAGCATTGCAAGAATCCCAGGCTTTAGTGTCTGCGACTGTGAATTCCAGCATGGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate