Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010059
Fusion event
HBV-CPA6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2268
Orient
+
Integrated sequence
CAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTC| |GGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCC
Host Sequence
Chromosome
chr8
Cytoband
q13.2
Reference genome
Start
End
68567571/67655336 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-124-1/Upstream/3276079; hsa-mir-10400/Downstream/6893207;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/311521, chr8-CpG: 64/Downstream/296854
Upstream sequence
tgaaattgaggcaataattaatagcctgccaaccaaaaggagtccaggaccagacagatacacagccaaattttaccagaggtacaaagaggagctgata
Downstream sequence
AGCTACCATTAGCACAGTGTCTGTGATTTCATATACTCTAATGAGCTGGGGAGAGAGAATACCTACTGTGACGTACAAAACTTAGGAATTAGGAGAAAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.