Basic Information
VIS ID
TVIS10010065
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1642
Orient
-
Integrated sequence
CGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTG| |CCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGT
Host Sequence
Chromosome
chr9
Cytoband
q32
Reference genome
GRCh37/hg19
Start
116545893/113783613 (Hg38)
End
116545893/113783613 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA9E
Nearest miRNA
hsa-let-7a-1/Upstream/1851444; hsa-mir-12126/Downstream/425821;
Nearest TSS
ENST00000422679/Upstream/132657; ENST00000481558/Downstream/92669;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/95439, chr9-CpG: 95/Downstream/92345
Nearby gene
RGS3(-185875) ; ZNF618(+92669) ;
Upstream sequence
AAATATATTTTGTGTAAAGAAGCCATATATAAATGAATGTGTTTATTTCTTTGTTGTGTTTAATCAAAGCTATCTTGGTCACATTCCATTATAAGCTAAT
Downstream sequence
tggttgtttcagtgggtggatggataggtagatgagtagatgggtaaacagataaatagatgaatagggagatggatggatagatgaatagatggatgat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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