Basic Information
VIS ID
TVIS10010067
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1925
Orient
+
Integrated sequence
TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA| |ATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCC
Host Sequence
Chromosome
chr9
Cytoband
p23
Reference genome
GRCh37/hg19
Start
12176139/12176139 (Hg38)
End
12176139/12176139 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-2/Upstream/6168235; hsa-let-7a-1/Downstream/6397167;
Nearest TSS
ENST00000422679/Upstream/16992; ENST00000473763/Downstream/509300;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/557551, chr9-CpG: 28/Downstream/599348
Nearby gene
PTPRD(-1563416) ; TYRP1(+517247) ;
Nearest cancer related gene
PTPRD(TSG, -1563416) ; TYRP1(OG, +517247) ;
Upstream sequence
AAAGACCCCAGACTGCCTGAACGCAGCACACAGGGTACCCCAGAGCACTAACGCTCTGCAGGTCTGGGGAGGGGGCCTTCATGTTGGTGCAACAGGACCC
Downstream sequence
taactcctgggtgatgccatggcaacaggaaactgacatggcacactagtgggcatgttttatggaaaactgattccacctcagccctttgttagctagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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