Basic Information
VIS ID
TVIS10010076
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
639
Orient
-
Integrated sequence
TCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTC| |CTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTA
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
155259924/156030259 (Hg38)
End
155259924/156030259 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/572644;
Nearest TSS
ENST00000429181/Upstream/13422;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/13356, None/Downstream
Nearby gene
IL9R(-19442) ;
Upstream sequence
TGTGAGTGAAAAGCAAGCCTTTGGGATTTGTCTCTCTCTCTCTTTCCTTGTTATAAAGGAAGCCTTATCTTTATGCATTTGGGGCTACCTGTGAACTTAC
Downstream sequence
ttaggggttagggttagggttaggggttagggttagggttaggggttaggggttaggggttaggggttagggtagggtagggtagggtagggagggttag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate