Basic Information
VIS ID
TVIS10010081
Fusion event
HBV-NEXMIF integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1812
Orient
-
Integrated sequence
AAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGC| |ACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCG
Host Sequence
Chromosome
chrX
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
74005699/74785864 (Hg38)
End
74005699/74785864 (Hg38)
Orient
+
Location type
Intronic
Target gene
NEXMIF
miRNAs that regulate target gene
hsa-mir-5580-3p ; hsa-mir-382-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-5011-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3133 ; hsa-mir-642a-5p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-216b-3p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-600 ; hsa-mir-6769a-3p ; hsa-mir-3943 ; hsa-mir-4323
Nearest miRNA
hsa-let-7f-2/Upstream/498507; hsa-mir-105-1/Downstream/2133409;
Nearest TSS
ENST00000429181/Upstream/45504; ENST00000373373/Downstream/139583;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/171102, chrX-CpG: 128/Downstream/138153
Upstream sequence
ttagggttagggtagggttagggttagggttaggggttaggggttagggtagggttagggtgagggtgagggtgagggtgagggtgagggtgagggttag
Downstream sequence
TGACTAAGCCATATGTCCTGAGAATGGTGGAGGAAGAGACTGTGCTTAGATAAGGTAATAGACAAAACTTATGAAATAAATCTGCTTTCATGAAATTTGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate