Basic Information
VIS ID
TVIS10010095
Fusion event
HBV-LINC01909 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2238
Orient
+
Integrated sequence
AGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGA| |GAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGA
Host Sequence
Chromosome
chr18
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
68015361/70348125 (Hg38)
End
68015361/70348125 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC01909
Nearest miRNA
hsa-mir-1-2/Upstream/3266439; hsa-mir-548av/Downstream/2505196;
Nearest TSS
ENST00000575820/Upstream/10815; ENST00000563639/Downstream/36466;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/58299, chr18-CpG: 21/Downstream/82445
Nearby gene
SOCS6(-17927) ; LINC01541(+1171839) ;
Upstream sequence
tttttagaatttctagcttttctgctctgtttttccccatctttgtggttttatctacctttgatctttgatgatggtgacgtacagatggcgttttggt
Downstream sequence
gtggatatcctttctgtttgttagttttccttctaacagtcaggaccttcagctgcaggtctgttggagtttgctggaggtccactccagaccctgtttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate