VISDB Viral Integration Site DataBase

VIS ID

TVIS10010098

Fusion event

HBV-SIPA1L3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1328

Orient

-

Integrated sequence

TCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATC| |GGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTT

Chromosome

chr19

Cytoband

q13.13

Reference genome

Start

End

38680643/38190003 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-615-3p ; hsa-mir-149-5p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-mir-210-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-4652-3p ; hsa-mir-4743-3p

Nearest miRNA

hsa-mir-10395/Upstream/2844376; hsa-let-7e/Downstream/1219620;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/106891, chr19-CpG: 21/Downstream/19690

Upstream sequence

CATGACGTCGTATCTGGGATTGCCTCTGCACGCCATGTGGATCTGCCATGCGTCTCTGGAGGGTGTGATTCTGGGTGGTGGGCCTGGCCCTTTCCTGGCT

Downstream sequence

GGGGGCTGCTGTCTGCTCCACAGACAGGACCCTGGGAGTGTCCGTGCACATGTGGCACTGTGGACTCATGTGAGCCTTTCTGAAGGACGCGTTTCCAGAA