VISDB Viral Integration Site DataBase

VIS ID

TVIS10010100

Fusion event

HBV-NOTCH2NLA integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1811

Orient

-

Integrated sequence

AAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAG| |CACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC

Chromosome

chr1

Cytoband

q21.1

Reference genome

Start

End

145237000/146201185 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-877-5p ; hsa-mir-452-5p ; hsa-mir-1279 ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-3941 ; hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-4793-3p ; hsa-mir-3130-3p ; hsa-mir-122-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-188-3p ; hsa-mir-4276 ; hsa-mir-532-3p ; hsa-mir-5190 ; hsa-mir-5094 ; hsa-mir-3174 ; hsa-mir-380-3p ; hsa-mir-411-3p ; hsa-mir-379-3p ; hsa-mir-4495 ; hsa-mir-6887-3p ; hsa-mir-194-5p ; hsa-mir-6826-3p ; hsa-mir-6795-3p

Nearest miRNA

hsa-mir-101-1/Upstream/350540; hsa-mir-1182/Downstream/2133294;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/148602, chr1-CpG: 98/Downstream/26904

Upstream sequence

ctttccctttcccttcctctctctcttttctttttttctttcttttttttcttttcttttctttcttttctctctctctctttctttAGCAGTTTATTAC

Downstream sequence

TCATTTGTGAGAATCAGGGAAGCACTGGGCTCAAGAAAGCCAATACCCCTTCTAGGGCTTACCCCCCATTTTAAAATTTAATATATTGGAATTTATATTG