Basic Information
VIS ID
TVIS10010101
Fusion event
HBV-KAZN integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr1
Cytoband
p36.21
Reference genome
GRCh37/hg19
Start
14842992/14516496 (Hg38)
End
14842992/14516496 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
KAZN
Nearest miRNA
hsa-mir-12136/Upstream/1937473; hsa-mir-101-1/Downstream/2342453;
Nearest TSS
ENST00000473358/Upstream/124921; ENST00000376028/Downstream/82208;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/623254, chr1-CpG: 116/Downstream/81618
Nearby gene
PRDM2(-691418) ; KAZN(+82221) ;
Upstream sequence
tgtagagagaggaacaagacctaggcctggtcaaccagcatttccatgcccttgaccacagtgattggctcagagatgagcacatgacccacgtcaggct
Downstream sequence
aatgagactcaagtctatgagtttatgcaaagtgttaggaagcagagttctcttCTGCGAGAAACAACAGACTCTTAACAAATATTTACTGAGTCAAGGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate