Basic Information
VIS ID
TVIS10010103
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2257
Orient
+
Integrated sequence
GTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATT| |TGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACG
Host Sequence
Chromosome
chr1
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
186720306/186751174 (Hg38)
End
186720306/186751174 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/6312784; hsa-mir-1182/Downstream/5965154;
Nearest TSS
ENST00000473358/Upstream/70552; ENST00000466600/Downstream/77779;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/70225, chr1-CpG: 56/Downstream/6057328
Nearby gene
PTGS2(-70747) ; PLA2G4A(+77726) ;
Upstream sequence
tgccatatgatacttgtatatgtgtgtgtataTCTCTTTTTCCTGTGCTCCATAGCACATTACAGGAGAATGATTGTTGTATTTTTGTTGCTTAGAGcac
Downstream sequence
tggttttcaaaattggttacagattggaatcacctgaagggcactaaaaagtactgatgtttgggtcccacacccagaaattctaatttgattggttttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate