Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010104
Fusion event
HBV-NFASC integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
End
204844523/204875395 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-8082 ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-4723-5p ; hsa-mir-5698 ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-6726-5p ; hsa-mir-920 ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1292-5p ; hsa-mir-6722-3p ; hsa-mir-4327 ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-4487 ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-6798-5p ; hsa-mir-7851-3p ; hsa-mir-490-3p ; hsa-mir-4290 ; hsa-mir-6825-5p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-5695 ; hsa-mir-342-3p ; hsa-mir-7113-5p ; hsa-mir-1228-3p ; hsa-mir-4640-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-1296-5p ; hsa-mir-2909 ; hsa-mir-4656 ; hsa-mir-3158-3p ; hsa-mir-4446-3p ; hsa-mir-5088-5p ; hsa-mir-4496 ; hsa-mir-140-3p ; hsa-mir-497-3p ; hsa-mir-181b-3p
Nearest miRNA
hsa-mir-101-1/Upstream/2872159; hsa-mir-1182/Downstream/572907;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/189638, chr1-CpG: 15/Downstream/106459
Upstream sequence
TGGGAGGCACTGAAGGGAAGATGGGAGACCCCAGCCTTCCACTGTTTTCCACTGGTCTAACCTCCAGGTTAGACCAGGAGCCTGGCAACACTACTGAGGC
Downstream sequence
TGTCTGCCTCCCAGAAGTCACATGTGCCTAAGAGGTGACTATATTTTGCTGGAGGAAGTGGAAAGAAGAACAGAGTAGGGAATCTGGAGGTGCCTGAGTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.