Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010107
Fusion event
HBV-MAGOH integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
Start
End
53692469/53226797 (Hg38)
Orient
+
Location type
downstream
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-12136/Upstream/1390395; hsa-mir-101-1/Downstream/827282;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/6078, chr1-CpG: 53/Downstream/11490
Upstream sequence
gaagaaaccaggtcatttgccttggaatttcctctcaatatggctgattgaagtcccactgtatttttaaaacatgtttctgtattctcttatttcctat
Downstream sequence
aaaatcataggtatatctagagagttgattagatttgatttttgggcaatactTCACATAGAATGTTAGTGTTCTACAAAGTAATTGAGAAGAGTTCACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.