VISDB Viral Integration Site DataBase

VIS ID

TVIS10010115

Fusion event

HBV-NEBL integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1731

Orient

-

Integrated sequence

ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC

Chromosome

chr10

Cytoband

p12.31

Reference genome

Start

End

21387026/21098097 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-125b-5p ; hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-4684-5p ; hsa-mir-6892-5p ; hsa-mir-942-5p ; hsa-mir-7845-5p ; hsa-mir-4475 ; hsa-mir-6507-3p ; hsa-mir-6883-3p ; hsa-mir-3156-3p ; hsa-mir-324-5p ; hsa-mir-3162-3p ; hsa-mir-4301 ; hsa-mir-140-3p

Nearest miRNA

hsa-mir-1265/Upstream/546051; hsa-mir-107/Downstream/398465;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/1280080, chr10-CpG: 149/Downstream/75102

Upstream sequence

AATCTTGATGTTTTCTGTAACCCTGGTAGCTAAGTGCTGATAACAACAATTATCTAAATGTTGCAAAAGGATGAAATCAGTAACAATGGGTCTACTGAAA

Downstream sequence

AGAGGCAAAAATGTGAGTGGATATGAATTTATAACAGCAATAGGGCTAAAGCTGCAGGGCCCTTTCATGTAGGAGGATAGCAacacacacacacactcat