THNSL1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010116
Fusion event
HBV-THNSL1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1795
Orient
-
Integrated sequence
CCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAA| |TTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT
Host Sequence
Chromosome
chr10
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
25247795/24958866 (Hg38)
End
25247795/24958866 (Hg38)
Orient
+
Location type
Intronic
Target gene
THNSL1
Nearest miRNA
hsa-mir-1265/Upstream/683085; hsa-mir-107/Downstream/3330392;
Nearest TSS
ENST00000439456/Upstream/5625; ENST00000524413/Downstream/57094;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/6014, chr10-CpG: 68/Downstream/57523
Nearby gene
PRTFDC1(-6262) ; ENKUR(+23113) ;
Upstream sequence
CAATAATGTCAGACCTGAGGAATATCAGCAGTAAGCGCTGGGCAGTTTCAGAGATATCCTCCCACTATCTCCCCTTCTGACCGGAACAGGAATTGGATAG
Downstream sequence
CTTCAGAGCAAAAGAATAATGTGTCCATGTGTTCCTCCAGATCTCTGAGTCCTGGCAGTCGACCTCAACTCTCTTGGCCACCATAAAGCAGTCATTGAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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