THNSL1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010117
Fusion event
HBV-THNSL1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2435
Orient
+
Integrated sequence
AGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATC| |TCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAAC
Host Sequence
Chromosome
chr10
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
25247797/24958868 (Hg38)
End
25247797/24958868 (Hg38)
Orient
-
Location type
Intronic
Target gene
THNSL1
Nearest miRNA
hsa-mir-1265/Upstream/683087; hsa-mir-107/Downstream/3330390;
Nearest TSS
ENST00000439456/Upstream/5627; ENST00000524413/Downstream/57092;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/6016, chr10-CpG: 68/Downstream/57521
Nearby gene
PRTFDC1(-6264) ; ENKUR(+23111) ;
Upstream sequence
ATAATGTCAGACCTGAGGAATATCAGCAGTAAGCGCTGGGCAGTTTCAGAGATATCCTCCCACTATCTCCCCTTCTGACCGGAACAGGAATTGGATAGCT
Downstream sequence
TCAGAGCAAAAGAATAATGTGTCCATGTGTTCCTCCAGATCTCTGAGTCCTGGCAGTCGACCTCAACTCTCTTGGCCACCATAAAGCAGTCATTGAAAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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