VISDB Viral Integration Site DataBase

VIS ID

TVIS10010120

Fusion event

HBV-EXOC6 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1821

Orient

+

Integrated sequence

TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA

Chromosome

chr10

Cytoband

q23.33

Reference genome

Start

End

94666049/92906292 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-31-5p ; hsa-mir-4668-3p ; hsa-mir-6739-3p ; hsa-mir-6853-3p ; hsa-mir-1206

Nearest miRNA

hsa-mir-107/Upstream/3313465; hsa-mir-1287/Downstream/3158023;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/57010, chr10-CpG: 255/Downstream/153977

Upstream sequence

tttctctatccctttattttttatctctttatgtctgtacattggaagtgattcagacatcacatagttgtgtcttattttttccactTAGAATTTAATA

Downstream sequence

AAAAtttcgtactttttcatgtatcttgtaaatttttttgtatgcaggacgttatatttaaaaagaatagaagagactgaagtaaCCAATTCTATGGTAG